This study will be an open-label trial to determine the functional effects of bilateral IA
injections of Zilretta into knee joints of 70 subjects with bilateral KL grade 2-4
symptomatic knee osteoarthritis (OA). Measurement and evaluation of outcomes at baseline, 6,
12 and 24 weeks will allow assessment of short and long-term effects, consistent with
Osteoarthritis Research Society International (OARSI) and Outcome Measures in Rheumatology
(OMERACT) recommendations.

This will be an open-label trial to describe the effects of cryoneurolysis with iovera┬░ on
symptom relief in patients with painful Kellgren-Lawrence (KL) grade 2-4 ankle osteoarthritis
(OA). The Foot and Ankle Outcome Score (FAOS) subscales will be used to assess outcomes at 6,
12 and 24 weeks after treatment.

A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the
efficacy of a single dose of Autologous Protein Solution (APS) in patients with
Osteoarthritis (OA) of the knee.