Active Studies

This is a two-part, Phase 1, open-label, multicenter, two-period, one-sequence study to
investigate the effect of itraconazole and rifampin on the PK of vemurafenib following
multiple 960 milligrams (mg) twice daily (BID) dosing in adult participants with
unresectable Stage IIIC or Stage IV metastatic melanoma positive for the BRAF V600 mutation,
or other malignant tumor types that harbor a V600-activating mutation of BRAF where the
participant has no acceptable standard treatment options.

The purpose of this research study is to help determine whether practicing resisting the
urge to smoke changes brain function or behavior among smokers.

Study A083-02 is a multicenter, Phase 2 study to evaluate the safety, tolerability,
pharmacodynamics (PD), efficacy, and pharmacokinetics (PK) of ACE 083 in patients with FSHD
to be conducted in two parts. Part 1 is open-label, dose-escalation and Part 2 is
randomized, double-blind, and placebo-controlled.

Researchers think there may be a relationship between fitness level and how people absorb nutrients.

What is involved? 

• VO2max treadmill test
• Body measurements - (Weight, height, body composition)
• Eating a 7-8 day meal plan that is provided
• Blood draw and oral glucose tolerance test
• Stool collection
• Keeping a 3-day food diary and activity record
• Completing questionnaires
• 4-5 visits ranging from 15min-2.5hour
(1-KU Med Center campus/3-4-fairway campus)

The purpose of this study is determine if the triplet combination of ribociclib, everolimus
and exemastane is effective in the treatment of locally advanced/metastatic breast cancer
following treatment with a CDK 4/6 inhibitor