Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus

The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve
cognitive function by having less effect on brain blood flow.

Eligibility Criteria

Inclusion Criteria:

- English speaking

- able to sign informed consent

- able to arrange transportation to and from study site

- without acute stroke, concussion or traumatic brain injury

- without acute medical issues at the time of participation

- after 12 weeks of the liver transplant surgery

Exclusion Criteria:

- are claustrophobic or have other contra-indication for magnetic resonance imaging

- have hearing or visual impairment

- are unable to read, write, speak or understand English

- have uncontrolled psychosis or seizure disorder or are currently using antipsychotics
or anti-epileptics

- within 12 weeks after transplant

Principal Investigator

Aditi Gupta, MD

Study Contact

Baljit Kaur,, 913-588-3708

Estimated Completion Date

Sunday, September 15, 2019 #