Early-Stage Polycystic Kidney Disease Biomarkers Repository Study

This observational study will collect blood and urine and clinical information from
individuals with early-stages of polycystic kidney disease (PKD), their unaffected siblings
and normal volunteers to create a biobank, also called a biorepository. The long-term goal
is to develop new knowledge on biological markers or biomarkers that indicate changes in the
disease progression. An understanding of biomarkers for early renal cyst growth will benefit
PKD patients as new therapies are being developed and tested.

Eligibility Criteria

Inclusion Criteria:

- Inclusion for early stage autosomal dominant polycystic kidney disease (ADPKD):

- Family history of PKD

- All races and ethnic groups

- Glomerular filtration rate (GFR) >80 ml/min per 1.73 m2

- Height Adjusted Total kidney volume less than 500 cc/m

- Inclusion for Healthy Volunteers:

- Male or female with no family history of kidney disease

- All races and ethnic groups

- Normal GFR

Exclusion Criteria:

- Non-insulin or insulin-dependent diabetes mellitus

- Systemic illness (i.e.systemic lupus erythematosus, vasculitis)

- Unable to provide written informed consent

- Unavailable for magnetic resonance imaging (MRI) and blood/urine collection

Principal Investigator

Darren P Wallace, PhD

Study Contact

Darren P Wallace, PhD, dwallace@kumc.edu, 913-588-3889

Estimated Completion Date

Monday, June 1, 2020

ClinicalTrials.gov #

NCT02936791
10/17/2016