Exploring the Safety and Efficacy of Low-dose Ketamine Infusions for Pain Control in Acute Burn Injury

The purpose of this study is to identify the optimal dosing strategy for low-dose ketamine
infusions in adult acute burn injury patients when used with usual pain medications.

Eligibility Criteria

Inclusion Criteria:

- Acute burn injury comprising 10-30% of total body surface. Burns severity may include
second or third degree burns

- Burn injury must have occurred within 72 hours of enrollment and randomization

- Subjects may be opioid-naïve or opioid non-naïve

- Anticipated stay in the burn unit is greater than 4 days, which is typically the
minimum length of stay for patients with this level of burn injury

Exclusion Criteria:

- Burn injury older than 72 hours

- Acute burn injury comprising >30% total body surface

- Patients who are intubated

- Patients who have contraindication to ketamine administration

Principal Investigator

Andrea Nicol, MD

Study Contact

Jamie Bischoff, RN, jbischoff@kumc.edu, 913-588-4583

Estimated Completion Date

Sunday, April 1, 2018

ClinicalTrials.gov #