Active Studies

The primary objective of this study is to demonstrate a pharmacodynamic effect of CK-2127107
on measures of skeletal muscle function or fatigability in patients with Spinal Muscular
Atrophy Types II-IV.

The aim of this study is to compare outcomes and cost-effectiveness of anterior versus
posterior surgical treatment for lumbar Isthmic Spondylolisthesis. The primary objective is
to compare treatment effectiveness in terms of functional outcomes as measured by Oswestry
Disability Index (ODI) v2.1a and to compare safety outcomes measured by treatment-related
adverse events. Secondary objectives are to compare treatments in terms of differences in
pain, quality of life, health utilities, and need for re-operation. Finally, a
cost-effectiveness analysis will be performed. This analysis will take the form of
cost-effectiveness if there is a difference in treatment effects or cost-minimization if
there is no difference in treatment efficacy.

The purpose of this study is to learn if taking a drug called Apixaban after an ablation
procedure keeps blood clots from forming and lowers the chance of having a stroke in
patients with ventricular tachycardia (VT).

This study will compare two different exercise and diet programs for Type 2 diabetic patients with diabetic neuropathy. Half of participants will be assigned at random to receive the diet and exercise counseling, typically provided to patients with diabetes while the other half of participants will receive supervised exercise and activity counseling, together with more intensive diet counseling. The study's primary goal is to compare the change in the number of small nerves that reach to the surface of the skin, as measured by skin biopsy, between the two treatment groups.