Active Studies

This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the
safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left
Atrial Appendage from the left atrium as an adjunct to planned pulmonary vein isolation
(PVI) catheter ablation in the treatment of subjects with symptomatic persistent or
longstanding persistent atrial fibrillation.

This study will be conducted in two stages:

- Limited Early Stage (Stage 1): up to 175 subjects at up to 15 sites

- Pivotal Stage (Stage 2): up to 600 subjects at up to 50 sites All patients from both
stages will be included in the primary analysis.

The purpose of this study is to determine if oxaloacetate (OAA) is safe and tolerable at
doses of up to 2 grams per day in people with Alzheimer's disease (AD).

The NeuroBlate® System (NBS) is a minimally invasive robotic laser thermotherapy tool that
is being manufactured by Monteris Medical. Since it received FDA clearance in April 2013,
the NBS has been used in over 300 procedures conducted at approximately 20 leading
institutions across United States. This is a prospective, multi-center registry that will
include data collection up to 12 months to evaluate procedural success, local control
failure rate, and QoL in up to 1,000 patients and up to 50 sites.

The goal of this study is to explore the impact of two different diets (conventional vs.
enhanced stop light) and two different delivery systems (face-to-face vs. remote) on weight
across 18 months in overweight and obese adolescents with intellectual and developmental

The purpose of this study is to identify genes that increase the risk of developing
vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results
of these studies will provide vasculitis researchers with insight into the causes of these
diseases and generate new ideas for diagnostic tests and therapies, and will be of great
interest to the larger communities of researchers investigating vasculitis and other
autoimmune, inflammatory, and vascular diseases.