Active Studies

This randomized phase III clinical trial studies how well tamoxifen citrate, anastrozole,
letrozole, or exemestane with or without chemotherapy work in treating patients with breast
cancer that has spread from where it began in the breast to surrounding normal tissue
(invasive). Estrogen can cause the growth of breast cancer cells. Hormone therapy, using
tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor
cells. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, may fight
breast cancer by lowering the amount of estrogen the body makes. Drugs used in chemotherapy
work in different ways to stop the growth of tumor cells, either by killing the cells, by
stopping them from dividing, or by stopping them from spreading. It is not yet known whether
giving tamoxifen citrate, anastrozole, letrozole, or exemestane is more effective with
combination chemotherapy in treating patients with breast cancer.

This randomized phase III trial studies standard or comprehensive radiation therapy in
treating patients with early-stage breast cancer who have undergone surgery. Radiation
therapy uses high-energy x rays to kill tumor cells. It is not yet known whether
comprehensive radiation therapy is more effective than standard radiation therapy in
treating patients with breast cancer

This research trial studies genetic testing in screening patients with stage IB-IIIA
non-small cell lung cancer that has been or will be removed by surgery. Studying the genes
in a patient's tumor cells may help doctors select the best treatment for patients that have
certain genetic changes.

This randomized phase III trial studies whether changes in diet and physical activity can
increase the length of survival without the return of cancer (progression-free survival)
compared with usual care in patients with previously treated stage II, III, or IV ovarian,
fallopian tube, or primary peritoneal cancer. A healthy diet and physical activity program
and counseling may help patients make healthier lifestyle choices. It is not yet known
whether changes in diet and exercise may help increase progression-free survival in patients
with previously treated cancer.

RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to
help focus thin beams of radiation directly on the tumor, and giving radiation therapy in
higher doses over a shorter period of time, may kill more tumor cells and have fewer side
effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways.
Some block the ability of tumor cells to grow and spread. Others find tumor cells and help
kill them or carry tumor-killing substances to them. It is not yet known whether radiation
therapy is more effective when given alone or together with cetuximab in treating patients
with head and neck cancer that has been removed by surgery.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it
works compared with radiation therapy given together with cetuximab in treating patients who
have undergone surgery for locally advanced head and neck cancer.

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