Active Studies

This research trial studies genetic testing in screening patients with stage IB-IIIA
non-small cell lung cancer that has been or will be removed by surgery. Studying the genes
in a patient's tumor cells may help doctors select the best treatment for patients that have
certain genetic changes.

The STREAM Study is a prospective longitudinal observational outcomes study that will
examine the reliability, validity and responsiveness of the PROMIS tools for clinical
research following orthopaedic trauma.

The overall goal of this project is to develop an integrative system of breast cancer risk
assessment based on epidemiologic and biologic risk variables, as well as to develop or
refine risk biomarkers which may be useful in predicting and monitoring response to
prevention interventions.

This randomized phase III trial studies whether changes in diet and physical activity can
increase the length of survival without the return of cancer (progression-free survival)
compared with usual care in patients with previously treated stage II, III, or IV ovarian,
fallopian tube, or primary peritoneal cancer. A healthy diet and physical activity program
and counseling may help patients make healthier lifestyle choices. It is not yet known
whether changes in diet and exercise may help increase progression-free survival in patients
with previously treated cancer.

RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to
help focus thin beams of radiation directly on the tumor, and giving radiation therapy in
higher doses over a shorter period of time, may kill more tumor cells and have fewer side
effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways.
Some block the ability of tumor cells to grow and spread. Others find tumor cells and help
kill them or carry tumor-killing substances to them. It is not yet known whether radiation
therapy is more effective when given alone or together with cetuximab in treating patients
with head and neck cancer that has been removed by surgery.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it
works compared with radiation therapy given together with cetuximab in treating patients who
have undergone surgery for locally advanced head and neck cancer.

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