Active Studies

Purpose: The objective of this study is to evaluate the safety of long-term treatment with Kuvan.

Interventions:
1. PKUDOS Registry
Patients with a confirmed diagnosis of Phenylketonuria (PKU) with hyperphenylalaninemia who have either received Kuvan therapy, or currently receive Kuvan therapy, or intend to begin receiving Kuvan therapy within 90 days of entering the registry.

Study objective: Researchers are interested to find out if Vitamin D supplementation can help prevent migraine headaches in adolescents.

Study objective: This study aims to examine the effects of aerobic exercise in individuals at high risk for Alzheimer's disease, as determined by an amyloid brain imaging scan. This study will observe whether 52 weeks of aerobic exercise is associated with a decrease in amyloid levels in the brain, as measured by the amyloid brain imaging scan.

Combination of Clopidogrel and Aspirin after Transient Ischemic Attack (POINT Trial)

Study objective: This study is designed to learn whether the combination of aspirin and clopidogrel reduces the risk of stroke, heart attacks, and other complications related to reduced supply of oxygen and nutrients to tissues (ischemia), compared to aspirin alone.

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