The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke. A single-blind, phase II, 3-site randomized controlled trial has been planned. Fifty persons >6 months post stroke will randomize to either moderate-intensity aerobic locomotor training or high-intensity interval locomotor training; each for 45 minutes, 3x/week for up to 36 total sessions over approximately 12 weeks. Clinical measures of walking function, aerobic fitness, daily walking activity and quality of life will be assessed at baseline (PRE) and after 4, 8 and 12 weeks of training (POST-4WK, POST-8WK, POST-12WK).

By doing this study, researchers hope to learn the effects of aerobic exercise on heart,
lung, and bone health in people who cannot walk after a stroke.

This study will compare two different exercise and diet programs for Type 2 diabetic patients with diabetic neuropathy. Half of participants will be assigned at random to receive the diet and exercise counseling, typically provided to patients with diabetes while the other half of participants will receive supervised exercise and activity counseling, together with more intensive diet counseling. The study's primary goal is to compare the change in the number of small nerves that reach to the surface of the skin, as measured by skin biopsy, between the two treatment groups.

Study objective: This study aims to examine the effects of aerobic exercise in individuals at high risk for Alzheimer's disease, as determined by an amyloid brain imaging scan. This study will observe whether 52 weeks of aerobic exercise is associated with a decrease in amyloid levels in the brain, as measured by the amyloid brain imaging scan.