This will be an open-label trial to describe the effects of cryoneurolysis with iovera┬░ on
symptom relief in patients with painful Kellgren-Lawrence (KL) grade 2-4 ankle osteoarthritis
(OA). The Foot and Ankle Outcome Score (FAOS) subscales will be used to assess outcomes at 6,
12 and 24 weeks after treatment.

The purpose of this study is to compare two different exercise programs to see if there are
differences after exercise in fibromyalgia (FM) symptoms and responses from the immune
system.

The aim of this study is to compare outcomes and cost-effectiveness of anterior versus
posterior surgical treatment for lumbar Isthmic Spondylolisthesis. The primary objective is
to compare treatment effectiveness in terms of functional outcomes as measured by Oswestry
Disability Index (ODI) v2.1a and to compare safety outcomes measured by treatment-related
adverse events. Secondary objectives are to compare treatments in terms of differences in
pain, quality of life, health utilities, and need for re-operation. Finally, a
cost-effectiveness analysis will be performed. This analysis will take the form of
cost-effectiveness if there is a difference in treatment effects or cost-minimization if
there is no difference in treatment efficacy.

The STREAM Study is a prospective longitudinal observational outcomes study that will
examine the reliability, validity and responsiveness of the PROMIS tools for clinical
research following orthopaedic trauma.