This will be an open-label trial to describe the effects of cryoneurolysis with iovera┬░ on
symptom relief in patients with painful Kellgren-Lawrence (KL) grade 2-4 ankle osteoarthritis
(OA). The Foot and Ankle Outcome Score (FAOS) subscales will be used to assess outcomes at 6,
12 and 24 weeks after treatment.

A double-blind, multicenter, randomized, controlled trial (RCT) that will evaluate the
efficacy of a single dose of Autologous Protein Solution (APS) in patients with
Osteoarthritis (OA) of the knee.