The purpose of this study is to find a protein (ex. Polycystin 1 or mucin and cadherin like
protein) in the urine that is changed after treatment of hydralazine.

This observational study will collect blood and urine and clinical information from
individuals with early-stages of polycystic kidney disease (PKD), their unaffected siblings
and normal volunteers to create a biobank, also called a biorepository. The long-term goal
is to develop new knowledge on biological markers or biomarkers that indicate changes in the
disease progression. An understanding of biomarkers for early renal cyst growth will benefit
PKD patients as new therapies are being developed and tested.