<p>Brain activity likely to be involved in control of brain-computer interfaces (BCI) will be recorded by electroencephalography (EEG), a non-invasive technique. These recordings will be used to control a computer-based augmentative and alternative communication (AAC) device.

The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke. A single-blind, phase II, 3-site randomized controlled trial has been planned. Fifty persons >6 months post stroke will randomize to either moderate-intensity aerobic locomotor training or high-intensity interval locomotor training; each for 45 minutes, 3x/week for up to 36 total sessions over approximately 12 weeks. Clinical measures of walking function, aerobic fitness, daily walking activity and quality of life will be assessed at baseline (PRE) and after 4, 8 and 12 weeks of training (POST-4WK, POST-8WK, POST-12WK).

By doing this study, researchers hope to learn the effects of aerobic exercise on heart,
lung, and bone health in people who cannot walk after a stroke.

SELECT is a multicenter, observational prospective study implementing a protocol to acquire
imaging and clinical variables known to affect clinical outcomes after endovascular therapy
in an effort to evaluate and compare the different selection methods and criteria currently
used in practice for acute ischemic stroke patients in the anterior circulation with large
vessel occlusion. The study aim is to evaluate prospectively different selection
methodologies for endovascular therapy, to compare them against each other to identify which
method provides the highest predictive ability in the selection of patients for IAT and to
devise a formula that predicts patients' outcomes.

This study will enroll patients based on the recent AHA guidelines (July 2015) regarding
treatment of patients with acute ischemic strokes and large artery occlusions in the
anterior circulation.

Combination of Clopidogrel and Aspirin after Transient Ischemic Attack (POINT Trial)

Study objective: This study is designed to learn whether the combination of aspirin and clopidogrel reduces the risk of stroke, heart attacks, and other complications related to reduced supply of oxygen and nutrients to tissues (ischemia), compared to aspirin alone.