The purpose of this study is to learn if the stoma boot camp is a good and effective way to
help people adapt to life with a stoma after surgery.

The study purpose is to demonstrate that ventricular tachycardia (VT) ablation using the
Niobe™ ES system results in superior outcomes compared to a manual approach in subjects with
ischemic scar VT in a low ejection fraction population.

The purpose of this study is to learn how effective each of the two dressings, Silverlon®
and AQUACEL® AG, are in preventing post cardiac implantable electronic devices (CIED)
procedure wound infections.

The aim of this study is to compare outcomes and cost-effectiveness of anterior versus
posterior surgical treatment for lumbar Isthmic Spondylolisthesis. The primary objective is
to compare treatment effectiveness in terms of functional outcomes as measured by Oswestry
Disability Index (ODI) v2.1a and to compare safety outcomes measured by treatment-related
adverse events. Secondary objectives are to compare treatments in terms of differences in
pain, quality of life, health utilities, and need for re-operation. Finally, a
cost-effectiveness analysis will be performed. This analysis will take the form of
cost-effectiveness if there is a difference in treatment effects or cost-minimization if
there is no difference in treatment efficacy.

This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the
safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left
Atrial Appendage from the left atrium as an adjunct to planned pulmonary vein isolation
(PVI) catheter ablation in the treatment of subjects with symptomatic persistent or
longstanding persistent atrial fibrillation.

This study will be conducted in two stages:

- Limited Early Stage (Stage 1): up to 175 subjects at up to 15 sites

- Pivotal Stage (Stage 2): up to 600 subjects at up to 50 sites All patients from both
stages will be included in the primary analysis.